Sam enlists everyone’s help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.

When a Supe kills the love of his life, A/V salesman Hughie Campbell teams up with Billy Butcher, a vigilante hell-bent on punishing corrupt Supes — and Hughie’s life will never be the same again.

When Lindsay is tipped off about a grieving father looking to avenge his daughter's death, Olinsky goes undercover as a hitman-for-hire. With Gang Intelligence lacking enough evidence to arrest the original gangbanger in question, the team works to reinvestigate the case. Meanwhile, Ruzek comes back after finishing his undercover assignment only to have Voight knock him down to patrol duty.

Magneto & Professor Xavier come face to face for the first time in years amid an exploding factory, while Sabretooth & Wolverine face off in the mansion.

Reporter Amelia accompanies Ollie and his mom, Dr. Akana, to investigate the mysterious Dinohenge statues; the trio run into an evil warrior named Void Knight and a threat that puts the entire world in danger.

Chicago Med braces for an influx of trauma patients when a pre-dawn pileup finds the hospital in full scramble mode. As a result of the storm and emergencies, supplies become limited and Goodwin, Dr. Manning and Dr. Halstead must deal with making an impossible decision. Meanwhile, Dr. Choi handles a severely burned patient who has one final request and Dr. Charles deals with an agitated patient.