Dr. Reese is contacted for help by a troubled teen in a psychiatric facility and Dr. Manning tries to help parents make a decision about their comatose daughter's surprise pregnancy. April begins to deal with repercussions from her personal life. Meanwhile, Dr. Choi and Dr. Rhodes work to save both a young girl from Ecuador who collapsed mid-flight, as well as her mother, who made great sacrifices for her daughter.

Wolverine must overcome his feelings for Jean, and Storm must overcome her crippling claustrophobia, when the team journeys into the sewer to rescue Jean Grey & Cyclops from a race of hideously deformed mutants known as Morlocks, and their leader Callisto, who wants to make Scott her king.

When a prominent judge is shot and killed while leaving a bar with Valdez, her integrity is called into question and Stone prohibits her from working the case. The team learns the judge's death is connected to a trial where he handed down a lenient sentence to a college rapist.

A murder leads Five-0 to investigate a centuries-old Oahu palace raid involving pirates, buried treasure and a killer who is using a stolen painting as a map. Also, the morning after their wedding, Kono and Adam are threatened and tortured by Gabriel, and Danny shows concern for McGarrett regarding Catherine's return to the island.