With most of the squad still trapped inside the burning warehouse fire, Chief Boden makes a risky last-minute decision in an effort to save his men. Dawson continues to deal with her father, who has new plans for himself. Brett's childhood friend Hope visits the Windy City and strikes the attention of someone within the firehouse, while Kidd goes head-to-head with her landlord. Meanwhile, a fire at a high school hits close to home for Boden.

Five-0 must work with rogue MI-6 agent Harry Langford to find a terrorist planning to cause nuclear reactors across Europe to meltdown. Also, McGarrett and Danny ask retired FBI profiler Alicia Brown to help them find their serial killer vigilante.