The murder of a navy machinist with high security clearance sends the team on a city-wide hunt tracking evidence. Also, Anna Kolcheck partners with Callen, and Sam assists Hetty in the on-going mole investigation.

Jess LaCroix and his elite team of FBI Fugitive Task Force agents track a doctor who's deeply involved in a world of organized crime, drugs and lies, and is on the run after a phone call records him delivering his wife's fatal shot.

Red acclimates to his new surroundings in federal prison, where he is challenged by an old rival. Samar goes undercover to stop a black market organization that fronts cash to criminals. Meanwhile, Liz and Jennifer continue their investigation into Red's past.

Mac and Jack partner with older versions of themselves, a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow. But when the antiquated computer needed to disable the warhead becomes inoperable, Mac must find a way to fix it with only duct tape and wire in time to prevent a new Cold War.

MacGyver and the team are in Malaysia to extract a terrorist groups’ money man, Ralph, who holds key intel to an impending attack. But the mission goes south when the man is shot, and now, with only a driver’s license and hand sanitizer available, MacGyver must keep Ralph alive in order to learn the terrorists’ plans.

MacGyver and the team attempt to rescue Sarah, Jack’s former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.

Angus MacGyver and Jack Dalton, special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to destroy hundreds of thousands of people with one single drop.

The district is in a state of change - Lindsay has moved to New York- and the CPD is under scrutiny about the corrupt nature of its institution. Under the watchful eye of the city, the team attempts to bust a gun deal that quickly turns dicey when innocent civilians and children get involved. Tension erupts when Chief brings in Denny Woods to review the shootout, and Halstead becomes a key player in the outcome of the case.

The International Response Team investigates the apparent suicide of an American in Colombia who emptied his bank account prior to his death.

Capt. Strand and the 126 help a husband whose wife "dies" when she is not upside down. Grace takes a call from a pizza delivery driver who is in for the shock of his life. Tommy is worried Trevor's young daughter is a bad seed as she attempts to break them up. Paul is hesitant to go on a date with Asha, who knows him prior to his transition.