The BAU steps in to help local law enforcement isolate a prime suspect for a ritualistic murder in Tallahassee, Fla., and soon after a second person who is related to the first victim is killed under similar circumstances. Prentiss is concerned about Garcia’s behavior in the aftermath of her abduction and has an idea of how to help with the healing process.

The BAU must determine what connects six people that each received a mysterious package in order to identify the Unsub. Simmons and his wife deal with their son's suspension from school.

When the mummified remains of numerous victims are found in the walls of an elderly couple's remote South Carolina home, Rossi, JJ and Simmons are dispatched to track down a trail of clues that date back over 20 years. The hunt becomes urgent after BAU learns the killer has a specific ritual of when to strike, and like clockwork another person goes missing. Rossi reconnects with his ex-wife.

When Reid and Garcia are abducted by Benjamin Merva, it's up to the rest of the team to find them. The BAU finds surprising clues in their own history to solve why the two heroes have been targeted by a mass murderer. It's a race to save them before a Believer's prophecy is fulfilled.

When Reid discovers former FBI Special Agent Owen Quinn locked inside a storage unit, the BAU questions the credibility of Quinn's bizarre accounts of searching for an UnSub that he named "The Strangler".

The BAU is called to Taos, N.M. to investigate an UnSub who is targeting his victims' temporal lobes.

The BAU is called to investigate a series of deaths in Virginia suspected by the Center for Disease Control to be caused by bio-terrorism; Garcia visits her stepbrother to take care of a family issue.

The BAU takes charge of a hostage situation at a law firm in D.C., where Matt Simmons’ wife, Kristy works.

The BAU travels to Chicago to investigate an unsub who leaves red roses on each victim. Also, Rossi gets an unexpected visit from his ex-wife, Krystall Richards.

The BAU is called to Oklahoma to investigate a murderous clown terrorizing the sleepy town of Guymon.