Harry Five-0 must help Duke after he is forced to steal crucial evidence from the police locker in exchange for his kidnapped granddaughter. Also, Jerry goes undercover at a mental health facility in order to solve a murder.

Harry Langford enlists McGarrett and Danny's help to track down Lady Sophie, a teenage British royal who has run away while under his protection. Also, Grover, Tani and Junior work a 25-year-old murder case after a mysterious Betamax tape arrives at 5-0 headquarters.

A hitman, Leroy Davis, McGarrett’s father failed to arrest comes to McGarrett to finally confess his crimes and admit where he buried his victims. Also, Jessie makes a dangerous decision that could ruin Adam’s life.

The ex-wife of the man who shot Danny comes to Oahu and reveals how Danny’s protection during a dangerous domestic dispute when he was in New Jersey helped save her life. Also, Tani and Junior are assigned to walk the beat as uniformed officers for the day, and Adam is framed for the murder of the crime boss he has been tracking.

Adam's mission to take down organized crime on the Island goes sideways when deadly chlorine gas he was using to bait a big fish falls into the wrong hands. Also, Adam begins to doubt Jessie's allegiance.

Tani and Junior go undercover as prospective parents in order to infiltrate a private school where the headmaster was murdered. Also, Adam's life is on the line when he is held captive and forced to produce a hidden massive amount of money.

McGarrett and Danny investigate the murder of a private detective whose client was killed the same way, and Adam sends Jessie into a dangerous situation with disastrous consequences. Also, Danny’s uncle, Vito, comes to town to help Danny and McGarrett get their restaurant up and running.

When the corpse of a diamond smuggler is stolen from a graveyard, Five-0 tracks down his partner, Voss, who will stop at nothing to retrieve their latest batch of contraband. Also, Adam recruits a new confidential informant, Jessie Nomura; Tani gets a devastating call; and McGarrett tasks Pua to find his and Danny's stolen tools.

When a man accused of killing his wife threatens to commit suicide, Grover reveals how he too was once on the brink of taking his own life.

When an FBI agent who was cracking down on organized crime is killed, McGarrett rounds up every gang-related criminal on the island to find the culprit. Also, McGarrett tasks Adam with forming a new division within Five-0 to take on organized crime.