MacGyver and Desi help a group of Syrian refugees who are being pursued by human traffickers. Also, in Los Angeles, Bozer is trapped in Oversight’s car which is rigged to explode.

When Nicholas Helman resurfaces to carry out a killing spree, the Phoenix is forced to get help from the one person who knows him best… his protégé, Murdoc.

MacGyver and team are asked to solve a locked-door mystery when a man working inside a remote, ultra-secure international seed vault disappears.

The Phoenix must recover the body of a pilot whose plane crashed while testing an experimental laser mapping system that MacGyver designed. Also, Riley tries to identify the hacker who tricked a SWAT team into arresting her and Elwood.

After a surprising introduction to Phoenix’s newest recruit, Desi, MacGyver and team are assigned to escort and protect an ATF (alcohol, tobacco, firearms) gun-sniffing dog who has a bounty on his head, only to discover they’re not the only ones crashing the weapon drop.

An international crime boss offers Matty a deal she can’t refuse – he’ll surrender himself into her custody if he’s allowed to return to the United States to watch his daughter walk down the aisle. MacGyver and team crash the wedding to ensure the crime lord doesn’t run, only to discover they’re not the only ones lying in wait at the event.

When MacGyver takes Riley and Bozer into the wilderness for a weekend of survival training, things take a turn when they run into a violent group of criminals who are searching the rugged backcountry for a lost crate of money. Also, Jack and Matty go on a road trip to place Matty’s ex-husband and his family in witness protection.