After one of Murdoc's go-to assassins agrees to hand over Murdoc to MacGyver in exchange for $10 million, the team finds itself protecting Murdoc from his former mentor, Nicholas Helman, who wants him dead. Also, Jack realizes he may still have feelings for Riley's mother, Diane.

When the team heads to New Orleans to track down the con artist who is posing as the wife of “Duke Jacoby,” one of Jack’s old CIA aliases, Jack finds himself in jeopardy when “Duke’s” old enemies resurface looking for revenge.

While Mac participates in a challenge for government operatives to create robotic combat machines, he must help his biggest competitor, Allie, when her vehicle is hacked and heads to the Pentagon. Also, Jack attends his high school reunion, hoping for a showdown with his old rival who beat him out for homecoming king.

When Mac and Jack are trapped inside Mac's house, which his nemesis, The Ghost, has rigged with explosives, Mac uses a karaoke mic and an audio transformer to let the team know that this bomb is a distraction for a bigger one. Also, through flashbacks, Mac and Jack's contentious first meeting unfolds.

The LAPD interrupts the team’s Christmas celebration to arrest Mac for terrorism when they find a body in a building destroyed by a bomb Mac built.

When 32 college students are stranded on a research ship in the Arctic Ocean with no heat and erupting fires, Mac develops an emotional connection to the group leader, via video chat, as he relays how to stay alive as they await a rescue ship. Also, Jack kidnaps Elwood to find out what scam he’s up to next, and Bozer’s feelings toward Leanna grow stronger.

Mac and the team follow a group of Indonesian mercenaries who are transporting a lethal amount of stolen nerve gas in the hopes of tracking them to their dangerous leader. Also, Jack confronts Elwood about Riley, and Bozer is pushed to his limit in spy school.

When MacGyver and Jack "steal" a priceless painting, using a table cloth and a shoe lace, in order to draw an infamous stolen art dealer out of hiding, they wind up getting conned out of the painting by the dealer's team. Also, Riley's estranged father, Elwood, asks to be part of her life, and Matty sends Bozer to a spy training camp.

MacGyver uses a heater and hot sauce to help a key presidential candidate in Ecuador receive a heart transplant he desperately needs after a rebel group tries to sabotage delivery of the organ.

Using a cassette player and a plastic bucket, Mac and the team attempt to extinguish a massive oil wellhead fire in a Nigerian village, set by a rebel group, which is trying to topple its government by destroying their most valuable resource.